WELCOME

Hello Arif here, read more about my world through this website.

I am an Electronics & Communication Engineer, currently pursuing my Ph.D. at the Indian Institute of Science, Bangalore. I work at Biomedical and Electronic Engineering Systems Laboratory, lead by Professor Hardik J. Pandya, in the Department of Electronic Systems Engineering, Division of EECS. My research focus is on developing intraoperative tools for augmenting the diagnosis of breast tumors. I am also working on the design and development of electronics systems and devices for biomedical applications.

RESEARCH WORK

Guided by Prof. Hardik J. Pandya at BEES Lab, Department of Electronic Systems Engineering, IISc Bengaluru.

Towards the development of an intraoperative probe using opto-acoustic modalities for breast cancer margin assessment
(Ph.D. Research Topic)

Proposed Solution: To develop an intraoperative probe for improving breast tumor margin using opto-acoustic sensing. We combine MEMS technology with optical technology to realize the probe. We are backed up by a team of expert oncologists and surgeons from Assam Medical College, Assam and University College London, London.

Status:

(a)- We have performed an experiment using an LED-based Time-Domain near-infrared spectroscopy (NIRS) system on formalin-fixed breast tissue (ex-vivo studies). The work was published in IEEE Sensors Journal.  

https://ieeexplore.ieee.org/document/9438686

(b)- We have performed another experiment using LED-based Polarization Spectroscopy tools based on the continuous-wave near-infrared spectroscopy (NIRS) technique on formalin-fixed breast tissue (ex-vivo studies). The work was published in the Journal of Biophotonics. https://doi.org/10.1002/jbio.202100282 

(c)- We have performed another study using the POLS-NIRDx system on fresh and formalin-fixed heart tissues and distinguishing between healthy and fibrotic heart tissues by quantifying the degree of linear polarization (DOLP) of the left ventricle (LV) and right ventricle (RV) heart tissues. The work was published in the Journal of Biomedical Opticshttps://doi.org/10.1117/1.JBO.27.5.055001

(d)- We extensively reviewed different engineering modalities that can be used for effective breast cancer diagnosis. The study was published in the IEEE Reviews in Biomedical Engineering. DOI: 10.1109/RBME.2022.3181700

JOURNAL ARTICLES

Toward the Development of Portable LED-based Polarization Spectroscopy Tools for  Breast Cancer Diagnosis

AUTHORS: 
Arif Mohd Kamal, Pal UM, Adithya Kumar, Gunabhi Ram Das, and Hardik J. Pandya.


JOURNAL: 
Journal of Biophotonics, 2021 September 21

https://doi.org/10.1002/jbio.202100282

ABSTRACT: A robust, affordable and portable light emitting diode-based diagnostic tools (POLS-NIRDx) using a polarizationsensitive (linear as well as circular polarization) technique were designed and developed to quantify the degree of linear polarization (DOLP), degree of circular polarization (DOCP). The study was performed on malignant (invasive ductal carcinoma) and adjacent normal ex-vivo biopsy tissues excised from N = 10 patients at the operating wavelengths of 850 and 940 nm. The average DOLP and DOCP values were lower for malignant than adjacent normal while operating at 850 and 940 nm. The highest accuracy was observed for DOLP (100%) and DOCP (80%) while operating at 850 nm, which reduced (80% for DOLP and 65% for DOCP) at 940 nm. This pilot study can be utilized as a differentiating factor to delineate malignant tissues from adjacent normal tissues.

KEYWORDS: biopsy tissue, breast cancer, circularly polarized light, linear polarized light, stokes parameter 

Towards Development of LED-based Time-Domain Near-IR Spectroscopy System for Delineating Breast Cancer from Adjacent Normal Tissue

AUTHORS: 
Kamal AM, Pal UM, Nayak A, Medisetti T, Arjun BS, Pandya HJ.


JOURNAL: 
IEEE Sensors Journal. 2021 May 21
DOI: 10.1109/JSEN.2021.3082850

ABSTRACT: Currently, the breast cancer diagnosis is performed by microscopic examination of thin slices of ex-vivo biopsy tissue by the pathologist. This paper proposes a robust and affordable LED-based time-domain near-infrared spectroscopy system (Spectro-IRTDx) to further aid the pathologist for rapid and accurate breast cancer diagnosis. The measurements are performed on formalin-fixed cancerous tissues (invasive ductal carcinoma) and their adjacent normal tissues obtained from N = 6 patients. The mean effective attenuation coefficient (µeff) for cancerous tissue is found to be 5.41 and 2.41 times higher than adjacent normal tissue, with good statistical significance (p = 0.00216) while operating at 850 nm and 940 nm, respectively. The average detected peak voltage (DPV) for adjacent normal tissue is found to be 3.44 and 4.16 times higher than cancerous tissue, with good statistical significance (p = 0.00216) while operating at 850 nm and 940 nm, respectively. The mean time of flight for cancerous tissue was 46 ns and 4 ns higher than the adjacent normal tissue while operating at 850 nm and 940 nm, respectively, with good statistical significance (p=0.00216) at 850 nm. The obtained results establish the proof-of-concept of the time-domain near-infrared spectroscopy for rapid diagnosis of core biopsy tissues.

KEYWORDS: Breast cancerBiomedical optical imagingSpectroscopyOptical scattering,

AUTHORS:

Arif Mohd Kamal, Uttam M. Pal,Manu K.S., and Hardik J. Pandya

CONFERENCES

Towards the Development of an Intraoperative Probe for Breast Cancer Margin Assessment

A multispectral diffuse reflectance spectroscopy (DRS) based intraoperative handheld probe (Multispectral-Pen) is designed and developed to characterize malignant tissues from adjacent normal tissues to assess the tumor margin accurately.

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Near-infrared polarization-based optical system for delineating healthy and fibrotic heart tissues

A near-infrared (NIR) linear polarization-based optical system is designed and developed for distinguishing between healthy and fibrotic heart tissues by quantifying the degree of linear polarization (DOLP) of the left ventricle (LV) and right ventricle (RV) tissues.

AUTHORS:

Twinkle, Arif Mohd Kamal, and Hardik J. Pandya

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Towards an Opto-Thermo-Acoustic (OTA) based Diagnostic Tool to Delineate Adjacent Normal from Cancerous Tissue for Cancer Margin Assessment

We propose an optical, thermal, and acoustic (OTA) based portable and cost-effective diagnostic tool (updated Hybrid Spectral-IRDx) to delineate adjacent normal from cancerous tissue during cancer margin assessment to ensure cancer resection.

AUTHORS:

Uttam M. Pal, Arif Mohd Kamal, Ashika Nayak, Tejaswi Medisetti, Hardik J. Pandya

CONFERENCE:

European Conferences on Biomedical Optics 2021.

https://www.osapublishing.org/abstract.cfm?uri=ECBO-2021-ETu4A.4

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Opto-acoustic multimodal system to delineate adjacent normal from cancerous tissue to aid intraoperative breast cancer excisional surgery

AUTHORS:

Uttam M. Pal, Arif Mohd Kamal,  Hardik J. Pandya

CONFERENCE:

IEEE CONNECT 2021

— We propose a multimodal system combining the optical and ultrasound technique to characterize the bulk optical and acoustic breast biopsy tissue property. The bulk optical property consisting of optical absorption coefficient (µa) and reduced scattering coefficient (µ's), and acoustic attenuation coefficient (α) are quantified to delineate between adjacent normal and cancerous breast biopsy tissues. It is observed that the cancerous tissues exhibit a higher acoustic attenuation coefficient and optical reduced scattering coefficient compared to adjacent normal tissues, a basis for delineation between adjacent normal and cancerous tissues.

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